Optimized induction of mitochondrial apoptosis for chemotherapy-free treatment of BCR-ABL+acute lymphoblastic leukemia

BCR-ABL+acute lymphoblastic leukemia (ALL) in adults has a poor prognosis with allogeneic stem cell transplantation (SCT) considered the best curative option for suitable patients. We here characterize the curative potential of BH3-mimetics differentially targeting mitochondrial BCL2-family members...

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Detalles Bibliográficos
Autores principales: Scherr, Michaela, Kirchhoff, Hanna, Battmer, Karin, Wohlan, Katharina, Lee, Chun-Wei, Ricke-Hoch, Melanie, Erschow, Sergej, Law, Edward, Kloos, Arnold, Heuser, Michael, Ganser, Arnold, Hilfiker-Kleiner, Denise, Heidenreich, Olaf, Eder, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756054/
https://www.ncbi.nlm.nih.gov/pubmed/30546081
http://dx.doi.org/10.1038/s41375-018-0315-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756054/
https://www.ncbi.nlm.nih.gov/pubmed/30546081
http://dx.doi.org/10.1038/s41375-018-0315-6

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