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Targeted killing of TNFR2-expressing tumor cells and T(regs) by TNFR2 antagonistic antibodies in advanced Sézary syndrome

Sézary syndrome (SS) is a rare form of cutaneous T-cell lymphoma often refractory to treatment. SS is defined as adenopathy, erythroderma with high numbers of atypical T cells. This offers an opportunity for new interventions and perhaps antibody-based therapeutic by virtue of its high expression of...

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Detalles Bibliográficos
Autores principales: Torrey, H, Khodadoust, M, Tran, L, Baum, D, Defusco, A, Kim, Y H, Faustman, D L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756055/
https://www.ncbi.nlm.nih.gov/pubmed/30356161
http://dx.doi.org/10.1038/s41375-018-0292-9