Regulation of PERK expression by FOXO3: a vulnerability of drug-resistant cancer cells

The major impediment to effective cancer therapy has been the development of drug resistance. The tumour suppressive transcription factor FOXO3 promotes cell cycle arrest, senescence and cell death, and mediates the cytotoxic and cytostatic functions of cancer therapeutics. In consequence, FOXO3 is...

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Detalles Bibliográficos
Autores principales: Alasiri, Glowi, Jiramongkol, Yannasittha, Zona, Stefania, Fan, Lavender Y. -N., Mahmud, Zimam, Gong, Gyungyub, Lee, Hee Jin, Lam, Eric W. -F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756075/
https://www.ncbi.nlm.nih.gov/pubmed/31312024
http://dx.doi.org/10.1038/s41388-019-0890-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756075/
https://www.ncbi.nlm.nih.gov/pubmed/31312024
http://dx.doi.org/10.1038/s41388-019-0890-7

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