Nuclear KIT induces a NFKBIB-RELA-KIT autoregulatory loop in imatinib-resistant gastrointestinal stromal tumors

Gastrointestinal stromal tumors (GISTs) are frequently driven by auto-activated, mutant KIT and have durable response to KIT tyrosine kinase inhibitor. However, acquired resistance is an increasing clinical issue in GIST patients receiving front-line imatinib therapy. Our previous studies showed the...

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Detalles Bibliográficos
Autores principales: Hsueh, Yuan-Shuo, Chang, Hui Hua, Shan, Yan-Shen, Sun, H. Sunny, Fletcher, Jonathan Alfred, Li, Chien-Feng, Chen, Li-Tzong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756115/
https://www.ncbi.nlm.nih.gov/pubmed/31363162
http://dx.doi.org/10.1038/s41388-019-0900-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756115/
https://www.ncbi.nlm.nih.gov/pubmed/31363162
http://dx.doi.org/10.1038/s41388-019-0900-9

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