Suppression of prostate tumor cell survival by antisense oligonucleotide-mediated inhibition of AR-V7 mRNA synthesis

One of the mechanisms by which advanced prostate cancer develops resistance to androgen deprivation therapy is the elevated expression of C-terminally truncated androgen receptor (AR) variants. These variants, such as AR-V7, originate from aberrant splicing of the AR pre-mRNA and the inclusion of a...

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Detalles Bibliográficos
Autores principales: Luna Velez, Maria V., Verhaegh, Gerald W., Smit, Frank, Sedelaar, J. P. Michiel, Schalken, Jack A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756119/
https://www.ncbi.nlm.nih.gov/pubmed/30664691
http://dx.doi.org/10.1038/s41388-019-0696-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756119/
https://www.ncbi.nlm.nih.gov/pubmed/30664691
http://dx.doi.org/10.1038/s41388-019-0696-7

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