Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality

Cell cycle regulation, especially faithful DNA replication and mitosis, are crucial to maintain genome stability. Cyclin-dependent kinase (CDK)/cyclin complexes drive most processes in cellular proliferation. In response to DNA damage, cell cycle surveillance mechanisms enable normal cells to arrest...

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Detalles Bibliográficos
Autores principales: Szmyd, Radoslaw, Niska-Blakie, Joanna, Diril, M. Kasim, Renck Nunes, Patrícia, Tzelepis, Konstantinos, Lacroix, Aurélie, van Hul, Noémi, Deng, Lih-Wen, Matos, Joao, Dreesen, Oliver, Bisteau, Xavier, Kaldis, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756125/
https://www.ncbi.nlm.nih.gov/pubmed/30190546
http://dx.doi.org/10.1038/s41388-018-0464-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756125/
https://www.ncbi.nlm.nih.gov/pubmed/30190546
http://dx.doi.org/10.1038/s41388-018-0464-0

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