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Emodin sensitizes human pancreatic cancer cells to EGFR inhibitor through suppressing Stat3 signaling pathway

BACKGROUND: Excessive expression of EGFR is closely related to tumor formation, transfer and deterioration, which has attracted much attention. EGFR overexpression may be detected in up to 90% of pancreatic tumors. However, drug resistance of EGFR inhibitors targeting treatment severely limits its c...

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Detalles Bibliográficos
Autores principales: Wang, Zhaohong, Chen, Hui, Chen, Jingjing, Hong, Zhong, Liao, Yi, Zhang, Qiyu, Tong, Hongfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756157/
https://www.ncbi.nlm.nih.gov/pubmed/31572001
http://dx.doi.org/10.2147/CMAR.S221877