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Deficiency of calcium/calmodulin-dependent serine protein kinase disrupts the excitatory-inhibitory balance of synapses by down-regulating GluN2B

Calcium/calmodulin-dependent serine protein kinase (CASK) is a membrane-associated guanylate kinase (MAGUK) protein that is associated with neurodevelopmental disorders. CASK is thought to have both pre- and postsynaptic functions, but the mechanism and consequences of its functions in the brain hav...

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Detalles Bibliográficos
Autores principales: Mori, Takuma, Kasem, Enas A., Suzuki-Kouyama, Emi, Cao, Xueshan, Li, Xue, Kurihara, Taiga, Uemura, Takeshi, Yanagawa, Toru, Tabuchi, Katsuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756202/
https://www.ncbi.nlm.nih.gov/pubmed/30610199
http://dx.doi.org/10.1038/s41380-018-0338-4