The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins

Flaviviruses translate their genomes as multi-pass transmembrane proteins at the endoplasmic reticulum (ER) membrane. Here, we show that the ER membrane protein complex (EMC) is indispensable for the expression of viral polyproteins. We demonstrated that EMC was essential for accurate folding and po...

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Detalles Bibliográficos
Autores principales: Ngo, Ashley M, Shurtleff, Matthew J, Popova, Katerina D, Kulsuptrakul, Jessie, Weissman, Jonathan S, Puschnik, Andreas S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756788/
https://www.ncbi.nlm.nih.gov/pubmed/31516121
http://dx.doi.org/10.7554/eLife.48469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756788/
https://www.ncbi.nlm.nih.gov/pubmed/31516121
http://dx.doi.org/10.7554/eLife.48469

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