Cargando…

Computational analysis of naturally occurring resistance-associated substitutions in genes NS3, NS5A, and NS5B among 86 subtypes of hepatitis C virus worldwide

BACKGROUND AND OBJECTIVE: Direct-acting antivirals (DAA) facing resistance continue to be used in some areas worldwide. Thus, identifying hepatitis C virus (HCV) genotypes/subtypes and loci with certain prevalent resistance-associated substitutions (RASs) deserves attention. We investigated the glob...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Ruihong, Geng, Dongfeng, Chi, Xiumei, Wang, Xiaomei, Gao, Xiuzhu, Xu, Hongqin, Shi, Ying, Guan, Yazhe, Wang, Yang, Jin, Jinglan, Ding, Yanhua, Niu, Junqi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756830/ https://www.ncbi.nlm.nih.gov/pubmed/31571951 http://dx.doi.org/10.2147/IDR.S218584

Ejemplares similares

Prevalence of Naturally-Occurring NS5A and NS5B Resistance-Associated Substitutions in Iranian Patients With Chronic Hepatitis C Infection
por: Rahimi, Pooneh, et al.
Publicado: (2021)

Prevalence of Single and Multiple Natural NS3, NS5A and NS5B Resistance-Associated Substitutions in Hepatitis C Virus Genotypes 1–4 in Italy
por: Bertoli, Ada, et al.
Publicado: (2018)

Performance of NS3, NS5a AND NS5b Hepatitis C Virus (HCV) Antiviral Resistance Sequencing Assays
por: Nutt, Jamie, et al.
Publicado: (2017)

Reflections of NS5 branes
por: Mertens, Adrian
Publicado: (2011)

Naturally occurring resistance mutations to inhibitors of HCV NS5A region and NS5B polymerase in DAA treatment-naïve patients
por: Paolucci, Stefania, et al.
Publicado: (2013)

Induction of Intrahepatic HCV NS4B, NS5A and NS5B-Specific Cellular Immune Responses following Peripheral Immunization
por: Lang Kuhs, Krystle A., et al.
Publicado: (2012)

Pretreatment Hepatitis C Virus NS5A/NS5B Resistance-Associated Substitutions in Genotype 1 Uruguayan Infected Patients
por: Aldunate, Fabián, et al.
Publicado: (2018)

Correction: Induction of Intrahepatic HCV NS4B, NS5A and NS5B-Specific Cellular Immune Responses following Peripheral Immunization
por: Lang Kuhs, Krystle A., et al.
Publicado: (2013)

Comment on “Pretreatment Hepatitis C Virus NS5A/NS5B Resistance-Associated Substitutions in Genotype 1 Uruguayan Infected Patients”
por: Eybpoosh, Sana, et al.
Publicado: (2018)

A Conserved NS3 Surface Patch Orchestrates NS2 Protease Stimulation, NS5A Hyperphosphorylation and HCV Genome Replication
por: Isken, Olaf, et al.
Publicado: (2015)

Distribution of naturally -occurring NS5B resistance-associated substitutions in Egyptian patients with chronic Hepatitis C
por: Ahmed, Hala Rady, et al.
Publicado: (2021)

A non-relativistic limit of NS-NS gravity
por: Bergshoeff, E. A., et al.
Publicado: (2021)

Response to: Comment on “Pretreatment Hepatitis C Virus NS5A/NS5B Resistance-Associated Substitutions in Genotype 1 Uruguayan Infected Patients”
por: Aldunate, Fabián, et al.
Publicado: (2019)

First report on molecular docking analysis and drug resistance substitutions to approved HCV NS5A and NS5B inhibitors amongst Iranian patients
por: Hasanshahi, Zahra, et al.
Publicado: (2021)

Correction: A Conserved NS3 Surface Patch Orchestrates NS2 Protease Stimulation, NS5A Hyperphosphorylation and HCV Genome Replication
por: Isken, Olaf, et al.
Publicado: (2016)

Evaluation of NS4A, NS4B, NS5 and 3′UTR Genetic Determinants of WNV Lineage 1 Virulence in Birds and Mammals
por: Fiacre, Lise, et al.
Publicado: (2023)

Structural and Functional Analysis of NS1 and NS2 Proteins of H1N1 Subtype
por: Salahuddin, Parveen, et al.
Publicado: (2010)

Characterization of Naturally Occurring NS5A and NS5B Polymorphisms in Patients Infected with HCV Genotype 3a Treated with Direct-Acting Antiviral Agents
por: Bartolini, Barbara, et al.
Publicado: (2017)

Longitudinal parameters of the LHC beam in the SPS: 25 ns/50 ns/75 ns bunch spacing
por: Papotti, G, et al.
Publicado: (2009)

Zika virus NS3 is a canonical RNA helicase stimulated by NS5 RNA polymerase
por: Xu, Shan, et al.
Publicado: (2019)

Subtype-Specific Prevalence of Hepatitis C Virus NS5A Resistance Associated Substitutions in Mainland China
por: Lu, Jie, et al.
Publicado: (2019)

Hepatitis C virus core, NS3, NS4B and NS5A are the major immunogenic proteins in humoral immunity in chronic HCV infection
por: Sillanpää, Maarit, et al.
Publicado: (2009)

Exploring the inhibitory potential of Nigella sativa against dengue virus NS2B/NS3 protease and NS5 polymerase using computational approaches
por: Mukhtar, Mamuna, et al.
Publicado: (2023)

Exploring NS3/4A, NS5A and NS5B proteins to design conserved subunit multi-epitope vaccine against HCV utilizing immunoinformatics approaches
por: Ikram, Aqsa, et al.
Publicado: (2018)

Characterization of NS5A and NS5B Resistance-Associated Substitutions from Genotype 1 Hepatitis C Virus Infected Patients in a Portuguese Cohort
por: Brandão, Ruben, et al.
Publicado: (2018)

Pestivirus NS2-3/NS3 Serine Peptidase
por: Tautz, Norbert, et al.
Publicado: (2013)

Orientifold dual for stuck NS5 branes
por: Feng, Bo, et al.
Publicado: (2001)

D-branes in the presence of NS5 branes
por: Rabinovici, Eliezer
Publicado: (2000)

NS5-branes, holography and CFT deformations
por: Fotopoulos, A, et al.
Publicado: (2010)

The Stimulatory Mechanism of Hepatitis C Virus NS5A Protein on the NS5B Catalyzed Replication Reaction In Vitro
por: Quezada, Elizabeth M, et al.
Publicado: (2013)

Naturally occurring mutations associated with resistance to HCV NS5B polymerase and NS3 protease inhibitors in treatment-naïve patients with chronic hepatitis C
por: Costantino, Angela, et al.
Publicado: (2015)

Seawater fungi-derived compound screening to identify novel small molecules against dengue virus NS5 methyltransferase and NS2B/NS3 protease
por: Hasan, Mahamudul, et al.
Publicado: (2022)

Over-expression and characterization of NS3 and NS5A of Hepatitis C virus genotype 3a
por: Anwar, Muhammad Ikram, et al.
Publicado: (2013)

Small-Molecule Inhibitor of Flaviviral NS3-NS5 Interaction with Broad-Spectrum Activity and Efficacy In Vivo
por: Celegato, Marta, et al.
Publicado: (2023)

Palmitoylation of Hepatitis C Virus NS2 Regulates Its Subcellular Localization and NS2-NS3 Autocleavage
por: Wu, Ming-Jhan, et al.
Publicado: (2019)

Spiky strings on AdS3 x S3 with NS-NS flux
por: Banerjee, Aritra, et al.
Publicado: (2014)

The co-existence of NS5A and NS5B resistance-associated substitutions is associated with virologic failure in Hepatitis C Virus genotype 1 patients treated with sofosbuvir and ledipasvir
por: Mawatari, Seiichi, et al.
Publicado: (2018)

Flavivirus NS3 and NS5 proteins interaction network: a high-throughput yeast two-hybrid screen
por: Le Breton, Marc, et al.
Publicado: (2011)

Characterisation of divergent flavivirus NS3 and NS5 protein sequences detected in Rhipicephalus microplus ticks from Brazil
por: Maruyama, Sandra Regina, et al.
Publicado: (2013)

NS simulator for beginners
por: Altman, Eitan, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_iuv23a2qj502qaj1kvd9m4e94n