Excision repair cross-complementing group-1 (ERCC1) induction kinetics and polymorphism are markers of inferior outcome in patients with colorectal cancer treated with oxaliplatin

BACKGROUND: ERCC1, a component of nucleotide excision repair pathway, is known to repair DNA breaks induced by platinum drugs. We sought to ascertain if ERCC1 expression dynamics and a single nucleotide polymorphism (SNP) rs11615 are biomarkers of sensitivity to oxaliplatin therapy in patients with...

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Detalles Bibliográficos
Autores principales: Rao, Devika, Mallick, Atrayee Basu, Augustine, Titto, Daroqui, Cecilia, Jiffry, Jeeshan, Merla, Amartej, Chaudhary, Imran, Seetharam, Raviraja, Sood, Arjun, Gajavelli, Srikanth, Aparo, Santiago, Rajdev, Lakshmi, Kaubisch, Andreas, Chuy, Jennifer, Negassa, Abdissa, Mariadason, John M., Maitra, Radhashree, Goel, Sanjay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756860/
https://www.ncbi.nlm.nih.gov/pubmed/31565185
http://dx.doi.org/10.18632/oncotarget.27140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756860/
https://www.ncbi.nlm.nih.gov/pubmed/31565185
http://dx.doi.org/10.18632/oncotarget.27140

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