PU-91 drug rescues human age-related macular degeneration RPE cells; implications for AMD therapeutics

Since mitochondrial dysfunction is implicated in the pathogenesis of AMD, this study is based on the premise that repurposing of mitochondria-stabilizing FDA-approved drugs such as PU-91, might rescue AMD RPE cells from AMD mitochondria-induced damage. The PU-91 drug upregulates PGC-1α which is a cr...

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Detalles Bibliográficos
Autores principales: Nashine, Sonali, Subramaniam, Sudhakar R., Chwa, Marilyn, Nesburn, Anthony, Kuppermann, Baruch D., Federoff, Howard, Kenney, M. Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756897/
https://www.ncbi.nlm.nih.gov/pubmed/31477635
http://dx.doi.org/10.18632/aging.102179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756897/
https://www.ncbi.nlm.nih.gov/pubmed/31477635
http://dx.doi.org/10.18632/aging.102179

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