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Trp–His covalent adduct in bilirubin oxidase is crucial for effective bilirubin binding but has a minor role in electron transfer
Unlike any protein studied so far, the active site of bilirubin oxidase from Myrothecium verrucaria contains a unique type of covalent link between tryptophan and histidine side chains. The role of this post-translational modification in substrate binding and oxidation is not sufficiently understood...
Autores principales: | Kovaľ, Tomáš, Švecová, Leona, Østergaard, Lars H., Skalova, Tereza, Dušková, Jarmila, Hašek, Jindřich, Kolenko, Petr, Fejfarová, Karla, Stránský, Jan, Trundová, Mária, Dohnálek, Jan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757100/ https://www.ncbi.nlm.nih.gov/pubmed/31548583 http://dx.doi.org/10.1038/s41598-019-50105-3 |
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