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Heterologous Expression of Rhizopus Oryzae CYP509C12 Gene in Rhizopus Nigricans Enhances Reactive Oxygen Species Production and 11α-Hydroxylation Rate of 16α, 17-Epoxyprogesterone

The 11α-hydroxylation of 16α, 17-epoxyprogesterone (EP) catalyzed by Rhizopus nigricans is crucial for the steroid industry. However, lower conversion rate of the biohydroxylation restricts its potential industrial application. The 11α-steroid hydroxylase CYP509C12 from R. oryzae were reported to pl...

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Detalles Bibliográficos
Autores principales: Shen, Chaohui, Gao, Xiyang, Li, Tao, Zhang, Jun, Gao, Yuqian, Qiu, Liyou, Zhang, Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758629/
https://www.ncbi.nlm.nih.gov/pubmed/31565466
http://dx.doi.org/10.1080/12298093.2019.1630201