Novel 4-arylaminoquinazolines bearing N,N-diethyl(aminoethyl)amino moiety with antitumour activity as EGFR(wt)-TK inhibitor

Herein, four novel 4-arylaminoquinazoline derivatives with N,N-diethyl(aminoethyl)amino moiety were designed, synthesised and evaluated on biological activities in vitro. All synthesised compounds have inhibitory effects against tumour cells (SW480, A549, A431 and NCI-H1975). In particular, 4-(3-chl...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Yaling, Chen, Li, Li, Xiabing, Gao, Li, Hao, Yunxia, Li, Baolin, Yan, Yaping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758725/
https://www.ncbi.nlm.nih.gov/pubmed/31530043
http://dx.doi.org/10.1080/14756366.2019.1667341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758725/
https://www.ncbi.nlm.nih.gov/pubmed/31530043
http://dx.doi.org/10.1080/14756366.2019.1667341

Ejemplares similares