Epigenetic Modifications Compromise Mitochondrial DNA Quality Control in the Development of Diabetic Retinopathy

PURPOSE: Diabetes causes dysfunction in the retinal mitochondria and increases base mismatches in their DNA (mtDNA). The enzyme responsible for repairing the base mismatches, MutL homolog 1 (Mlh1), is compromised. Diabetes also favors many epigenetic modifications and activates DNA methylation machi...

Descripción completa

Detalles Bibliográficos
Autores principales: Mohammad, Ghulam, Radhakrishnan, Rakesh, Kowluru, Renu A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2019
Materias:
Retinal Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759036/
https://www.ncbi.nlm.nih.gov/pubmed/31546260
http://dx.doi.org/10.1167/iovs.19-27602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759036/
https://www.ncbi.nlm.nih.gov/pubmed/31546260
http://dx.doi.org/10.1167/iovs.19-27602

Ejemplares similares