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Epigenetic Modifications Compromise Mitochondrial DNA Quality Control in the Development of Diabetic Retinopathy

PURPOSE: Diabetes causes dysfunction in the retinal mitochondria and increases base mismatches in their DNA (mtDNA). The enzyme responsible for repairing the base mismatches, MutL homolog 1 (Mlh1), is compromised. Diabetes also favors many epigenetic modifications and activates DNA methylation machi...

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Detalles Bibliográficos
Autores principales:	Mohammad, Ghulam, Radhakrishnan, Rakesh, Kowluru, Renu A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2019
Materias:	Retinal Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759036/ https://www.ncbi.nlm.nih.gov/pubmed/31546260 http://dx.doi.org/10.1167/iovs.19-27602

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