Trp53 null and R270H mutant alleles have comparable effects in regulating invasion, metastasis and gene expression in mouse colon tumorigenesis

Somatic APC (adenomatous polyposis coli), TP53, KRAS mutations are present in roughly 80%, 60%, and 40%, respectively, of human colorectal cancers (CRCs). Most TP53 mutant alleles in CRCs encode missense mutant proteins with loss-of-function (LOF) of p53’s transcriptional activity and dominant negat...

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Detalles Bibliográficos
Autores principales: Tang, Jinyu, Feng, Ying, Kuick, Rork, Green, Megan, Green, Maranne, Sakamoto, Naoya, Kurosu, Yuki, Lin, Jeffry, Cho, Kathleen R, Fearon, Eric R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759392/
https://www.ncbi.nlm.nih.gov/pubmed/31148594
http://dx.doi.org/10.1038/s41374-019-0269-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759392/
https://www.ncbi.nlm.nih.gov/pubmed/31148594
http://dx.doi.org/10.1038/s41374-019-0269-y

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