Endogenous fluctuations of OCT4 and SOX2 bias pluripotent cell fate decisions

SOX2 and OCT4 are pioneer transcription factors playing a key role in embryonic stem (ES) cell self‐renewal and differentiation. How temporal fluctuations in their expression levels bias lineage commitment is unknown. Here, we generated knock‐in reporter fusion ES cell lines allowing to monitor endo...

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Detalles Bibliográficos
Autores principales: Strebinger, Daniel, Deluz, Cédric, Friman, Elias T, Govindan, Subashika, Alber, Andrea B, Suter, David M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759502/
https://www.ncbi.nlm.nih.gov/pubmed/31556488
http://dx.doi.org/10.15252/msb.20199002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759502/
https://www.ncbi.nlm.nih.gov/pubmed/31556488
http://dx.doi.org/10.15252/msb.20199002

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