CRBN Is a Negative Regulator of Bactericidal Activity and Autophagy Activation Through Inhibiting the Ubiquitination of ECSIT and BECN1

Cereblon (CRBN) as a multifunctional protein has been extensively studied. Here, we show that CRBN is a negative regulator of bactericidal activity and autophagy activation. Mitochondrial localization of CRBN was significantly increased in response to Toll-like receptor 4 (TLR4) stimulation. CRBN in...

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Detalles Bibliográficos
Autores principales: Kim, Mi-Jeong, Min, Yoon, Shim, Jae-Hyuck, Chun, Eunyoung, Lee, Ki-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759600/
https://www.ncbi.nlm.nih.gov/pubmed/31620128
http://dx.doi.org/10.3389/fimmu.2019.02203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759600/
https://www.ncbi.nlm.nih.gov/pubmed/31620128
http://dx.doi.org/10.3389/fimmu.2019.02203

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