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The dark genome and pleiotropy: challenges for precision medicine
Surprisingly we remain ignorant of the function of the majority of genes in the human and mouse genomes. The dark genome is a major obstacle to the interpretation of the function of human genetic variation and its impact on disease. At the same time, pleiotropy, how individual variants influence mul...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759675/ https://www.ncbi.nlm.nih.gov/pubmed/31444567 http://dx.doi.org/10.1007/s00335-019-09813-4 |