Cystathionine β-synthase (CBS) deficiency suppresses erythropoiesis by disrupting expression of heme biosynthetic enzymes and transporter

The reduced iron usage induced by the suppression of erythropoiesis is a major cause of the systemic iron overload in CBS knockout (CBS(−/−)) mice. However, the relevant mechanisms are unknown. Here, we examined changes in granulocyte/erythroid cell ratios, iron content, and expression of iron-metab...

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Detalles Bibliográficos
Autores principales: Zhao, Peng, Qian, Christopher, Chen, Yun-Jin, Sheng, Yuan, Ke, Ya, Qian, Zhong-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760157/
https://www.ncbi.nlm.nih.gov/pubmed/31551410
http://dx.doi.org/10.1038/s41419-019-1951-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760157/
https://www.ncbi.nlm.nih.gov/pubmed/31551410
http://dx.doi.org/10.1038/s41419-019-1951-0

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