Cargando…

The transferability of lipid loci across African, Asian and European cohorts

Most genome-wide association studies are based on samples of European descent. We assess whether the genetic determinants of blood lipids, a major cardiovascular risk factor, are shared across populations. Genetic correlations for lipids between European-ancestry and Asian cohorts are not significan...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kuchenbaecker, Karoline, Telkar, Nikita, Reiker, Theresa, Walters, Robin G., Lin, Kuang, Eriksson, Anders, Gurdasani, Deepti, Gilly, Arthur, Southam, Lorraine, Tsafantakis, Emmanouil, Karaleftheri, Maria, Seeley, Janet, Kamali, Anatoli, Asiki, Gershim, Millwood, Iona Y., Holmes, Michael, Du, Huaidong, Guo, Yu, Kumari, Meena, Dedoussis, George, Li, Liming, Chen, Zhengming, Sandhu, Manjinder S., Zeggini, Eleftheria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760173/ https://www.ncbi.nlm.nih.gov/pubmed/31551420 http://dx.doi.org/10.1038/s41467-019-12026-7

Ejemplares similares

Insights into the genetic architecture of haematological traits from deep phenotyping and whole-genome sequencing for two Mediterranean isolated populations
por: Kuchenbaecker, Karoline, et al.
Publicado: (2022)

Genome-wide meta-analysis of 92 cardiometabolic protein serum levels
por: Gilly, Arthur, et al.
Publicado: (2023)

Very low-depth sequencing in a founder population identifies a cardioprotective APOC3 signal missed by genome-wide imputation
por: Gilly, Arthur, et al.
Publicado: (2016)

Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits
por: Southam, Lorraine, et al.
Publicado: (2017)

Whole-genome sequencing analysis of the cardiometabolic proteome
por: Gilly, Arthur, et al.
Publicado: (2020)

Population‐wide copy number variation calling using variant call format files from 6,898 individuals
por: Png, Grace, et al.
Publicado: (2019)

Gene-based whole genome sequencing meta-analysis of 250 circulating proteins in three isolated European populations
por: Gilly, Arthur, et al.
Publicado: (2022)

Very low-depth whole-genome sequencing in complex trait association studies
por: Gilly, Arthur, et al.
Publicado: (2019)

Erratum. Cardiometabolic Risk in a Rural Ugandan Population. Diabetes Care 2013;36;e143
por: Murphy, Georgina A.V., et al.
Publicado: (2017)

Erratum. The Use of Anthropometric Measures for Cardiometabolic Risk Identification in a Rural African Population. Diabetes Care 2013;37:e64–e65
por: Murphy, Georgina A.V., et al.
Publicado: (2017)

Urbanicity and Lifestyle Risk Factors for Cardiometabolic Diseases in Rural Uganda: A Cross-Sectional Study
por: Riha, Johanna, et al.
Publicado: (2014)

Cardiometabolic Risk in a Rural Ugandan Population
por: Murphy, Georgina A.V., et al.
Publicado: (2013)

Mapping the serum proteome to neurological diseases using whole genome sequencing
por: Png, Grace, et al.
Publicado: (2021)

Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits
por: Gilly, Arthur, et al.
Publicado: (2018)

Author Correction: Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits
por: Gilly, Arthur, et al.
Publicado: (2018)

Prevalence of Dyslipidaemia and Associated Risk Factors in a Rural Population in South-Western Uganda: A Community Based Survey
por: Asiki, Gershim, et al.
Publicado: (2015)

Correction: Prevalence of Dyslipidaemia and Associated Risk Factors in a Rural Population in South-Western Uganda: A Community Based Survey
por: Asiki, Gershim, et al.
Publicado: (2017)

Genetic characterization of Greek population isolates reveals strong genetic drift at missense and trait-associated variants
por: Panoutsopoulou, Kalliope, et al.
Publicado: (2014)

A Dietary Pattern with High Sugar Content Is Associated with Cardiometabolic Risk Factors in the Pomak Population
por: Farmaki, Aliki-Eleni, et al.
Publicado: (2019)

Identifying causal serum protein–cardiometabolic trait relationships using whole genome sequencing
por: Png, Grace, et al.
Publicado: (2022)

Adverse pregnancy outcomes in rural Uganda (1996–2013): trends and associated factors from serial cross sectional surveys
por: Asiki, Gershim, et al.
Publicado: (2015)

Replication of Established Common Genetic Variants for Adult BMI and Childhood Obesity in Greek Adolescents: The TEENAGE Study
por: Ntalla, Ioanna, et al.
Publicado: (2013)

Long reads: their purpose and place
por: Pollard, Martin O, et al.
Publicado: (2018)

Complimentary Methods for Multivariate Genome-Wide Association Study Identify New Susceptibility Genes for Blood Cell Traits
por: Fatumo, Segun, et al.
Publicado: (2019)

Combination therapy as a potential risk factor for the development of type 2 diabetes in patients with schizophrenia: the GOMAP study
por: Mamakou, Vasiliki, et al.
Publicado: (2018)

Association between early life antibiotic use and childhood overweight and obesity: a narrative review
por: Partap, Uttara, et al.
Publicado: (2018)

Using population isolates in genetic association studies
por: Hatzikotoulas, Konstantinos, et al.
Publicado: (2014)

The effect of childhood stunting and wasting on adolescent cardiovascular diseases risk and educational achievement in rural Uganda: a retrospective cohort study
por: Asiki, Gershim, et al.
Publicado: (2019)

Prevalence, Types, Risk Factors and Clinical Correlates of Anaemia in Older People in a Rural Ugandan Population
por: Mugisha, Joseph O., et al.
Publicado: (2013)

Mendelian randomisation study of body composition and depression in people of East Asian ancestry highlights potential setting-specific causality
por: O’Loughlin, Jessica, et al.
Publicado: (2023)

Making a livelihood at the fish-landing site: exploring the pursuit of economic independence amongst Ugandan women
por: Pearson, Georgina, et al.
Publicado: (2013)

Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
por: Carland, Corinne, et al.
Publicado: (2023)

Pathways to understanding the genomic aetiology of osteoarthritis
por: Cibrián Uhalte, Elena, et al.
Publicado: (2017)

Feasibility of using smartphones by village health workers for pregnancy registration and effectiveness of mobile phone text messages on reduction of homebirths in rural Uganda
por: Asiki, Gershim, et al.
Publicado: (2018)

Distinct genetic architectures and environmental factors associate with host response to the γ2-herpesvirus infections
por: Sallah, Neneh, et al.
Publicado: (2020)

The African Genome Variation Project shapes medical genetics in Africa
por: Gurdasani, Deepti, et al.
Publicado: (2014)

Recruitment and retention of women in fishing communities in HIV prevention research
por: Ssetaala, Ali, et al.
Publicado: (2015)

Factors associated with dropout in a long term observational cohort of fishing communities around lake Victoria, Uganda
por: Abaasa, Andrew, et al.
Publicado: (2015)

Factors associated with vaccination completion and retention among HIV negative female sex workers enrolled in a simulated vaccine efficacy trial in Kampala, Uganda
por: Mayanja, Yunia, et al.
Publicado: (2019)

Spicy food consumption and risk of gastrointestinal-tract cancers: findings from the China Kadoorie Biobank
por: Chan, Wing Ching, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_v61onoiuepj6cg9plocb4k1okr