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OPA1 overexpression ameliorates mitochondrial cristae remodeling, mitochondrial dysfunction, and neuronal apoptosis in prion diseases
Prion diseases caused by the cellular prion protein (PrP(C)) conversion into a misfolded isoform (PrP(Sc)) are associated with multiple mitochondrial damages. We previously reported mitochondrial dynamic abnormalities and cell death in prion diseases via modulation of a variety of factors. Optic atr...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760175/ https://www.ncbi.nlm.nih.gov/pubmed/31551424 http://dx.doi.org/10.1038/s41419-019-1953-y |