OPA1 overexpression ameliorates mitochondrial cristae remodeling, mitochondrial dysfunction, and neuronal apoptosis in prion diseases

Prion diseases caused by the cellular prion protein (PrP(C)) conversion into a misfolded isoform (PrP(Sc)) are associated with multiple mitochondrial damages. We previously reported mitochondrial dynamic abnormalities and cell death in prion diseases via modulation of a variety of factors. Optic atr...

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Detalles Bibliográficos
Autores principales: Wu, Wei, Zhao, Deming, Shah, Syed Zahid Ali, Zhang, Xixi, Lai, Mengyu, Yang, Dongming, Wu, Xiaoqian, Guan, Zhiling, Li, Jie, Zhao, Huafen, Li, Wen, Gao, Hongli, Zhou, Xiangmei, Qiao, Jian, Yang, Lifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760175/
https://www.ncbi.nlm.nih.gov/pubmed/31551424
http://dx.doi.org/10.1038/s41419-019-1953-y

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