Targeted metabolomic analysis of nitric oxide/L-arginine pathway metabolites in dementia: association with pathology, severity, and structural brain changes

L-Arginine/NO pathway is altered in Alzheimer disease (AD). Its clinical relevance and pathway status in vascular dementia (VaD) are unknown. Using targeted metabolomics (a liquid chromatography-mass spectrometry) we assessed L-arginine, L-citrulline, dimethylamine (DMA), asymmetric dimethyl arginin...

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Detalles Bibliográficos
Autores principales: Fleszar, Mariusz G., Wiśniewski, Jerzy, Zboch, Marzena, Diakowska, Dorota, Gamian, Andrzej, Krzystek-Korpacka, Małgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760237/
https://www.ncbi.nlm.nih.gov/pubmed/31551443
http://dx.doi.org/10.1038/s41598-019-50205-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760237/
https://www.ncbi.nlm.nih.gov/pubmed/31551443
http://dx.doi.org/10.1038/s41598-019-50205-0

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