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Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA
Self-amplifying RNA (saRNA) is a promising biotherapeutic tool that has been used as a vaccine against both infectious diseases and cancer. saRNA has been shown to induce protein expression for up to 60 days and elicit immune responses with lower dosing than messenger RNA (mRNA). Because saRNA is a...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760535/ https://www.ncbi.nlm.nih.gov/pubmed/31300730 http://dx.doi.org/10.1038/s41434-019-0095-2 |