Stable pantothenamide bioisosteres: novel antibiotics for Gram-positive bacteria

The emergence of multidrug resistant bacteria has prioritized the development of new antibiotics. N-substituted pantothenamides, analogs of the natural compound pantetheine, were reported to target bacterial coenzyme A biosynthesis, but these compounds have never reached the clinic due to their inst...

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Detalles Bibliográficos
Autores principales: Jansen, Patrick A. M., van der Krieken, Danique A., Botman, Peter N. M., Blaauw, Richard H., Cavina, Lorenzo, Raaijmakers, Eline M., de Heuvel, Erik, Sandrock, Julia, Pennings, Lian J., Hermkens, Pedro H. H., Zeeuwen, Patrick L. J. M., Rutjes, Floris P. J. T., Schalkwijk, Joost
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760626/
https://www.ncbi.nlm.nih.gov/pubmed/31171848
http://dx.doi.org/10.1038/s41429-019-0196-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760626/
https://www.ncbi.nlm.nih.gov/pubmed/31171848
http://dx.doi.org/10.1038/s41429-019-0196-6

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