Lactacystin: first-in-class proteasome inhibitor still excelling and an exemplar for future antibiotic research

Lactacystin exemplifies the role that serendipity plays in drug discovery and why “finding things without actually looking for them” retains such a pivotal role in the search for the useful properties of chemicals. The first proteasome inhibitor discovered, lactacystin stimulated new possibilities i...

Descripción completa

Detalles Bibliográficos
Autores principales: Ōmura, Satoshi, Crump, Andy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760633/
https://www.ncbi.nlm.nih.gov/pubmed/30755736
http://dx.doi.org/10.1038/s41429-019-0141-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760633/
https://www.ncbi.nlm.nih.gov/pubmed/30755736
http://dx.doi.org/10.1038/s41429-019-0141-8

Ejemplares similares