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Lactacystin: first-in-class proteasome inhibitor still excelling and an exemplar for future antibiotic research
Lactacystin exemplifies the role that serendipity plays in drug discovery and why “finding things without actually looking for them” retains such a pivotal role in the search for the useful properties of chemicals. The first proteasome inhibitor discovered, lactacystin stimulated new possibilities i...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760633/ https://www.ncbi.nlm.nih.gov/pubmed/30755736 http://dx.doi.org/10.1038/s41429-019-0141-8 |