Astrocyte-selective AAV gene therapy through the endogenous GFAP promoter results in robust transduction in the rat spinal cord following injury

Adeno-associated viral (AAV) vectors are a promising system for transgene delivery into the central nervous system (CNS) based on their safety profile and long-term gene expression. Gene delivery to the CNS has largely been neuron centric but advances in AAV technology are facilitating the developme...

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Detalles Bibliográficos
Autores principales: Griffin, Jarred M., Fackelmeier, Barbara, Fong, Dahna M., Mouravlev, Alexander, Young, Deborah, O’Carroll, Simon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760677/
https://www.ncbi.nlm.nih.gov/pubmed/30962538
http://dx.doi.org/10.1038/s41434-019-0075-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760677/
https://www.ncbi.nlm.nih.gov/pubmed/30962538
http://dx.doi.org/10.1038/s41434-019-0075-6

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