CRISPR/Cas9-based editing of a sensitive transcriptional regulatory element to achieve cell type-specific knockdown of the NEMO scaffold protein

The use of alternative promoters for the cell type-specific expression of a given mRNA/protein is a common cell strategy. NEMO is a scaffold protein required for canonical NF-κB signaling. Transcription of the NEMO gene is primarily controlled by two promoters: one (promoter B) drives NEMO transcrip...

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Detalles Bibliográficos
Autores principales: Babaei, Milad, Liu, Yuekun, Wuerzberger-Davis, Shelly M., McCaslin, Ethan Z., DiRusso, Christopher J., Yeo, Alan T., Kagermazova, Larisa, Miyamoto, Shigeki, Gilmore, Thomas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760803/
https://www.ncbi.nlm.nih.gov/pubmed/31553754
http://dx.doi.org/10.1371/journal.pone.0222588

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760803/
https://www.ncbi.nlm.nih.gov/pubmed/31553754
http://dx.doi.org/10.1371/journal.pone.0222588

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