The ClpX chaperone controls autolytic splitting of Staphylococcus aureus daughter cells, but is bypassed by β-lactam antibiotics or inhibitors of WTA biosynthesis

β-lactam antibiotics interfere with cross-linking of the bacterial cell wall, but the killing mechanism of this important class of antibiotics is not fully understood. Serendipitously we found that sub-lethal doses of β-lactams rescue growth and prevent spontaneous lysis of Staphylococcus aureus mut...

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Detalles Bibliográficos
Autores principales: Jensen, Camilla, Bæk, Kristoffer T., Gallay, Clement, Thalsø-Madsen, Ida, Xu, Lijuan, Jousselin, Ambre, Ruiz Torrubia, Fernando, Paulander, Wilhelm, Pereira, Ana R., Veening, Jan-Willem, Pinho, Mariana G., Frees, Dorte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760813/
https://www.ncbi.nlm.nih.gov/pubmed/31518377
http://dx.doi.org/10.1371/journal.ppat.1008044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760813/
https://www.ncbi.nlm.nih.gov/pubmed/31518377
http://dx.doi.org/10.1371/journal.ppat.1008044

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