A mutation in mouse Krüppel-like factor 15 alters the gut microbiome and response to obesogenic diet

We identified a mouse strain, HLB444, carrying an N-ethyl-N-nitrosourea (ENU)-induced mutation in a highly conserved C2H2 zinc-finger DNA binding motif of the transcriptional regulator KLF15 that exhibits resistance to diet-induced obesity. Characterization of the HLB444 mutant model on high-fat and...

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Detalles Bibliográficos
Autores principales: Svenson, Karen L., Long, Lauren L., Ciciotte, Steven L., Adams, Mark D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760833/
https://www.ncbi.nlm.nih.gov/pubmed/31553739
http://dx.doi.org/10.1371/journal.pone.0222536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760833/
https://www.ncbi.nlm.nih.gov/pubmed/31553739
http://dx.doi.org/10.1371/journal.pone.0222536

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