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A mutation in mouse Krüppel-like factor 15 alters the gut microbiome and response to obesogenic diet
We identified a mouse strain, HLB444, carrying an N-ethyl-N-nitrosourea (ENU)-induced mutation in a highly conserved C2H2 zinc-finger DNA binding motif of the transcriptional regulator KLF15 that exhibits resistance to diet-induced obesity. Characterization of the HLB444 mutant model on high-fat and...
Autores principales: | Svenson, Karen L., Long, Lauren L., Ciciotte, Steven L., Adams, Mark D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760833/ https://www.ncbi.nlm.nih.gov/pubmed/31553739 http://dx.doi.org/10.1371/journal.pone.0222536 |
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