Structural insights into the EGO-TC–mediated membrane tethering of the TORC1-regulatory Rag GTPases

The Rag/Gtr GTPases serve as a central module in the nutrient-sensing signaling network upstream of TORC1. In yeast, the anchoring of Gtr1-Gtr2 to membranes depends on the Ego1-Ego2-Ego3 ternary complex (EGO-TC), resulting in an EGO-TC-Gtr1-Gtr2 complex (EGOC). EGO-TC and human Ragulator share no ob...

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Detalles Bibliográficos
Autores principales: Zhang, Tianlong, Péli-Gulli, Marie-Pierre, Zhang, Zhen, Tang, Xin, Ye, Jie, De Virgilio, Claudio, Ding, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760929/
https://www.ncbi.nlm.nih.gov/pubmed/31579828
http://dx.doi.org/10.1126/sciadv.aax8164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760929/
https://www.ncbi.nlm.nih.gov/pubmed/31579828
http://dx.doi.org/10.1126/sciadv.aax8164

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