Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage

Colibactin is an assumed human gut bacterial genotoxin, whose biosynthesis is linked to clb genomic island that distributes widespread in pathogenic and commensal human enterobacteria. Colibactin-producing gut microbes promote colon tumor formation and enhance progression of colorectal cancer via DN...

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Detalles Bibliográficos
Autores principales: Li, Zhong-Rui, Li, Jie, Cai, Wenlong, Lai, Jennifer Y. H., McKinnie, Shaun M. K., Zhang, Wei-Peng, Moore, Bradley S., Zhang, Wenjun, Qian, Pei-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761029/
https://www.ncbi.nlm.nih.gov/pubmed/31527851
http://dx.doi.org/10.1038/s41557-019-0317-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761029/
https://www.ncbi.nlm.nih.gov/pubmed/31527851
http://dx.doi.org/10.1038/s41557-019-0317-7

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