In silico Analysis of Gamma-Secretase-Complex Mutations in Hidradenitis Suppurativa Demonstrates Disease-Specific Substrate Recognition and Cleavage Alterations

Background: Familial Hidradenitis Suppurativa and Familial Alzheimer's Disease are both associated with Gamma-Secretase Complex mutations; however, the two diseases are not epidemiologically associated. Understanding the molecular differences between the two diseases may aid in the development...

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Detalles Bibliográficos
Autores principales: Frew, John W., Navrazhina, Kristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761225/
https://www.ncbi.nlm.nih.gov/pubmed/31608281
http://dx.doi.org/10.3389/fmed.2019.00206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761225/
https://www.ncbi.nlm.nih.gov/pubmed/31608281
http://dx.doi.org/10.3389/fmed.2019.00206

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