Unexpected Compensatory Increase in Shank3 Transcripts in Shank3 Knock-Out Mice Having Partial Deletions of Exons

Genetic variants of the SH3 and multiple ankyrin repeat domains 3 (SHANK3) gene, which encodes excitatory postsynaptic core scaffolds cause numerous brain disorders. Several lines of Shank3 knock-out (KO) mice with deletions of different Shank3 exons have previously been generated and characterized....

Descripción completa

Detalles Bibliográficos
Autores principales: Jin, Chunmei, Kang, Hyae Rim, Kang, Hyojin, Zhang, Yinhua, Lee, Yeunkum, Kim, Yoonhee, Han, Kihoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761322/
https://www.ncbi.nlm.nih.gov/pubmed/31607862
http://dx.doi.org/10.3389/fnmol.2019.00228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761322/
https://www.ncbi.nlm.nih.gov/pubmed/31607862
http://dx.doi.org/10.3389/fnmol.2019.00228

Ejemplares similares