Cargando…
PLS3 Overexpression Delays Ataxia in Chp1 Mutant Mice
Many neurodegenerative disorders share common pathogenic pathways such as endocytic defects, Ca(2+) misregulation and defects in actin dynamics. Factors acting on these shared pathways are highly interesting as a therapeutic target. Plastin 3 (PLS3), a proven protective modifier of spinal muscular a...
Autores principales: | Janzen, Eva, Wolff, Lisa, Mendoza-Ferreira, Natalia, Hupperich, Kristina, Delle Vedove, Andrea, Hosseinibarkooie, Seyyedmohsen, Kye, Min Jeong, Wirth, Brunhilde |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761326/ https://www.ncbi.nlm.nih.gov/pubmed/31607845 http://dx.doi.org/10.3389/fnins.2019.00993 |
Ejemplares similares
-
CHP1 reduction ameliorates spinal muscular atrophy pathology by restoring calcineurin activity and endocytosis
por: Janzen, Eva, et al.
Publicado: (2018) -
Biallelic CHP1 mutation causes human autosomal recessive ataxia by impairing NHE1 function
por: Mendoza-Ferreira, Natalia, et al.
Publicado: (2018) -
Evaluation of potential effects of Plastin 3 overexpression and low-dose SMN-antisense oligonucleotides on putative biomarkers in spinal muscular atrophy mice
por: Strathmann, Eike A., et al.
Publicado: (2018) -
Neurocalcin Delta Knockout Impairs Adult Neurogenesis Whereas Half Reduction Is Not Pathological
por: Upadhyay, Aaradhita, et al.
Publicado: (2019) -
Genetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy
por: Walsh, Melissa B., et al.
Publicado: (2020)