Molecular Basis of Class A β-Lactamase Inhibition by Relebactam

β-Lactamase production is the major β-lactam resistance mechanism in Gram-negative bacteria. β-Lactamase inhibitors (BLIs) efficacious against serine β-lactamase (SBL) producers, especially strains carrying the widely disseminated class A enzymes, are required. Relebactam, a diazabicyclooctane (DBO)...

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Detalles Bibliográficos
Autores principales: Tooke, Catherine L., Hinchliffe, Philip, Lang, Pauline A., Mulholland, Adrian J., Brem, Jürgen, Schofield, Christopher J., Spencer, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761529/
https://www.ncbi.nlm.nih.gov/pubmed/31383664
http://dx.doi.org/10.1128/AAC.00564-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761529/
https://www.ncbi.nlm.nih.gov/pubmed/31383664
http://dx.doi.org/10.1128/AAC.00564-19

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