TBAJ-876 Retains Bedaquiline’s Activity against Subunits c and ε of Mycobacterium tuberculosis F-ATP Synthase

The antituberculosis drug bedaquiline (BDQ) inhibits Mycobacterium tuberculosis F-ATP synthase by interfering with two subunits. Drug binding to the c subunit stalls the rotation of the c ring, while binding to the ε subunit blocks coupling of c ring rotation to ATP synthesis at the catalytic α(3):β...

Descripción completa

Detalles Bibliográficos
Autores principales: Sarathy, Jickky Palmae, Ragunathan, Priya, Shin, Joon, Cooper, Christopher B., Upton, Anna M., Grüber, Gerhard, Dick, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Mechanisms of Action: Physiological Effects
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761534/
https://www.ncbi.nlm.nih.gov/pubmed/31358589
http://dx.doi.org/10.1128/AAC.01191-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761534/
https://www.ncbi.nlm.nih.gov/pubmed/31358589
http://dx.doi.org/10.1128/AAC.01191-19

Ejemplares similares