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TBAJ-876 Retains Bedaquiline’s Activity against Subunits c and ε of Mycobacterium tuberculosis F-ATP Synthase

The antituberculosis drug bedaquiline (BDQ) inhibits Mycobacterium tuberculosis F-ATP synthase by interfering with two subunits. Drug binding to the c subunit stalls the rotation of the c ring, while binding to the ε subunit blocks coupling of c ring rotation to ATP synthesis at the catalytic α(3):β...

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Detalles Bibliográficos
Autores principales:	Sarathy, Jickky Palmae, Ragunathan, Priya, Shin, Joon, Cooper, Christopher B., Upton, Anna M., Grüber, Gerhard, Dick, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2019
Materias:	Mechanisms of Action: Physiological Effects
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761534/ https://www.ncbi.nlm.nih.gov/pubmed/31358589 http://dx.doi.org/10.1128/AAC.01191-19

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