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Spatial and temporal regulation of the endoproteolytic activity of the SPS-sensor–controlled Ssy5 signaling protease

The Saccharomyces cerevisiae Ssy5 signaling protease is a core component of the plasma membrane (PM)–localized SPS (Ssy1-Ptr3-Ssy5) sensor. In response to extracellular amino acids, the SPS-sensor orchestrates the proteasomal degradation of the inhibitory Ssy5 prodomain. The unfettered catalytic (Ca...

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Detalles Bibliográficos
Autores principales: Martins, António, Ring, Andreas, Omnus, Deike J., Heessen, Stijn, Pfirrmann, Thorsten, Ljungdahl, Per O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761765/
https://www.ncbi.nlm.nih.gov/pubmed/31461372
http://dx.doi.org/10.1091/mbc.E19-02-0096