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Aza-proline effectively mimics l-proline stereochemistry in triple helical collagen

The prevalence of l-amino acids in biomolecules has been shown to have teleological importance in biomolecular structure and self-assembly. Recently, biophysical studies have demonstrated that natural l-amino acids can be replaced with non-natural achiral aza-amino acids in folded protein structures...

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Detalles Bibliográficos
Autores principales: Kasznel, Alexander J., Harris, Trevor, Porter, Nicholas J., Zhang, Yitao, Chenoweth, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761869/
https://www.ncbi.nlm.nih.gov/pubmed/31588264
http://dx.doi.org/10.1039/c9sc02211b