Nucleophile-intercepted Beckmann fragmentation reactions

We describe the first examples of nucleophile-intercepted Beckmann fragmentations of indoline oximes. This reaction uses MsCl as a promoter to give cyano chlorides and is believed to proceed through an aziridinium intermediate via a double stereoinvertive process. Mechanistic insights have led to th...

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Detalles Bibliográficos
Autores principales: Touchette, Samuel J., Dunkley, Evan M., Lowder, Leah L., Wu, Jimmy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761917/
https://www.ncbi.nlm.nih.gov/pubmed/31588331
http://dx.doi.org/10.1039/c9sc00926d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761917/
https://www.ncbi.nlm.nih.gov/pubmed/31588331
http://dx.doi.org/10.1039/c9sc00926d

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