Synthesis and reactivity of precolibactin 886

The clb gene cluster encodes the biosynthesis of metabolites known as precolibactins and colibactins. The clb pathway is found in gut commensal E. coli, and clb metabolites are thought to initiate colorectal cancer via DNA cross-linking. Here we report confirmation of the structural assignment of th...

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Detalles Bibliográficos
Autores principales: Healy, Alan R., Wernke, Kevin M., Kim, Chung Sub, Lees, Nicholas R., Crawford, Jason M., Herzon, Seth B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761996/
https://www.ncbi.nlm.nih.gov/pubmed/31548676
http://dx.doi.org/10.1038/s41557-019-0338-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761996/
https://www.ncbi.nlm.nih.gov/pubmed/31548676
http://dx.doi.org/10.1038/s41557-019-0338-2

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