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Human osteocyte expression of Nerve Growth Factor: The effect of Pentosan Polysulphate Sodium (PPS) and implications for pain associated with knee osteoarthritis

Pentosan polysulphate sodium (PPS) is a promising therapeutic agent for blocking knee pain in individuals with knee osteoarthritis (KOA). The mode of action of PPS in this context is unknown. We hypothesised that the osteocyte, being the principal cell type in the sub-chondral bone, was capable of e...

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Detalles Bibliográficos
Autores principales: Stapledon, Catherine J. M., Tsangari, Helen, Solomon, Lucian B., Campbell, David G., Hurtado, Plinio, Krishnan, Ravi, Atkins, Gerald J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6762051/
https://www.ncbi.nlm.nih.gov/pubmed/31557169
http://dx.doi.org/10.1371/journal.pone.0222602