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Novel roles of ER stress in repressing neural activity and seizures through Mdm2- and p53-dependent protein translation

Seizures can induce endoplasmic reticulum (ER) stress, and sustained ER stress contributes to neuronal death after epileptic seizures. Despite the recent debate on whether inhibiting ER stress can reduce neuronal death after seizures, whether and how ER stress impacts neural activity and seizures re...

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Detalles Bibliográficos
Autores principales: Liu, Dai-Chi, Eagleman, Daphne E., Tsai, Nien-Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6762060/
https://www.ncbi.nlm.nih.gov/pubmed/31557161
http://dx.doi.org/10.1371/journal.pgen.1008364