Cargando…

The monothiol glutaredoxin GrxD is essential for sensing iron starvation in Aspergillus fumigatus

Efficient adaptation to iron starvation is an essential virulence determinant of the most common human mold pathogen, Aspergillus fumigatus. Here, we demonstrate that the cytosolic monothiol glutaredoxin GrxD plays an essential role in iron sensing in this fungus. Our studies revealed that (i) GrxD...

Descripción completa

Detalles Bibliográficos
Autores principales:	Misslinger, Matthias, Scheven, Mareike Thea, Hortschansky, Peter, López-Berges, Manuel Sánchez, Heiss, Katharina, Beckmann, Nicola, Heigl, Thomas, Hermann, Martin, Krüger, Thomas, Kniemeyer, Olaf, Brakhage, Axel A., Haas, Hubertus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6762210/ https://www.ncbi.nlm.nih.gov/pubmed/31525190 http://dx.doi.org/10.1371/journal.pgen.1008379

Ejemplares similares

Effect of the Monothiol Glutaredoxin GrxD on 2,4-Diacetylphloroglucinol Biosynthesis and Biocontrol Activity of Pseudomonas fluorescens 2P24
por: Dong, Qiuling, et al.
Publicado: (2022)

The Monothiol Glutaredoxin Grx4 Regulates Iron Homeostasis and Virulence in Cryptococcus neoformans
por: Attarian, Rodgoun, et al.
Publicado: (2018)

The Monothiol Glutaredoxin Grx4 Influences Iron Homeostasis and Virulence in Ustilago maydis
por: McCotter, Sean W., et al.
Publicado: (2023)

Sequence and structural characterization of Trx-Grx type of monothiol glutaredoxins from Ashbya gossypii
por: Yadav, Saurabh, et al.
Publicado: (2013)

The bZIP Transcription Factor HapX Is Post-Translationally Regulated to Control Iron Homeostasis in Aspergillus fumigatus
por: López-Berges, Manuel Sánchez, et al.
Publicado: (2021)

Genetic suppressors of Δgrx3 Δgrx4, lacking redundant multidomain monothiol yeast glutaredoxins, rescue growth and iron homeostasis
por: Li, Guichun, et al.
Publicado: (2022)

Erratum for Attarian et al., “The Monothiol Glutaredoxin Grx4 Regulates Iron Homeostasis and Virulence in Cryptococcus neoformans”
por: Attarian, Rodgoun, et al.
Publicado: (2019)

Proteomic profiling of the monothiol glutaredoxin Grx3 reveals its global role in the regulation of iron dependent processes
por: Alkafeef, Selma S., et al.
Publicado: (2020)

The monothiol glutaredoxin Grx4 influences thermotolerance, cell wall integrity, and Mpk1 signaling in Cryptococcus neoformans
por: Hu, Guanggan, et al.
Publicado: (2021)

Crystal structure of yeast monothiol glutaredoxin Grx6 in complex with a glutathione-coordinated [2Fe–2S] cluster
por: Abdalla, Mohnad, et al.
Publicado: (2016)

One cysteine is enough: A monothiol Grx can functionally replace all cytosolic Trx and dithiol Grx
por: Zimmermann, Jannik, et al.
Publicado: (2020)

Structure of Arabidopsis chloroplastic monothiol glutaredoxin AtGRXcp
por: Li, Lenong, et al.
Publicado: (2010)

Drugging the Undruggable Trypanosoma brucei Monothiol Glutaredoxin 1
por: Favaro, Annagiulia, et al.
Publicado: (2023)

Evolution and Cellular Function of Monothiol Glutaredoxins: Involvement in Iron-Sulphur Cluster Assembly
por: Vilella, Felipe, et al.
Publicado: (2004)

Structure analysis of yeast glutaredoxin Grx6 protein produced in Escherichia coli
por: Abdalla, Mohnad, et al.
Publicado: (2018)

Structural basis of HapE(P88L)-linked antifungal triazole resistance in Aspergillus fumigatus
por: Hortschansky, Peter, et al.
Publicado: (2020)

Glutaredoxins employ parallel monothiol–dithiol mechanisms to catalyze thiol–disulfide exchanges with protein disulfides
por: Ukuwela, Ashwinie A., et al.
Publicado: (2017)

Characterization of Three New Glutaredoxin Genes in the Arbuscular Mycorrhizal Fungus Rhizophagus irregularis: Putative Role of RiGRX4 and RiGRX5 in Iron Homeostasis
por: Tamayo, Elisabeth, et al.
Publicado: (2016)

Overexpression of Rice Glutaredoxin OsGrx_C7 and OsGrx_C2.1 Reduces Intracellular Arsenic Accumulation and Increases Tolerance in Arabidopsis thaliana
por: Verma, Pankaj K., et al.
Publicado: (2016)

The fungal CCAAT-binding complex and HapX display highly variable but evolutionary conserved synergetic promoter-specific DNA recognition
por: Furukawa, Takanori, et al.
Publicado: (2020)

Monothiol Glutaredoxins Function in Storing and Transporting [Fe(2)S(2)] Clusters Assembled on IscU Scaffold Proteins
por: Shakamuri, Priyanka, et al.
Publicado: (2012)

Corrigendum: Overexpression of Rice Glutaredoxin OsGrx_C7 and OsGrx_C2.1 Reduces Intracellular Arsenic Accumulation and Increases Tolerance in Arabidopsis thaliana
por: Verma, Pankaj K., et al.
Publicado: (2016)

Overexpression of the CC-type glutaredoxin, OsGRX6 affects hormone and nitrogen status in rice plants
por: El-Kereamy, Ashraf, et al.
Publicado: (2015)

Corrigendum (2): Overexpression of Rice Glutaredoxin OsGrx_C7 and OsGrx_C2.1 Reduces Intracellular Arsenic Accumulation and Increases Tolerance in Arabidopsis thaliana
por: Verma, Pankaj K., et al.
Publicado: (2017)

Regulatory interactions for iron homeostasis in Aspergillus fumigatus inferred by a Systems Biology approach
por: Linde, Jörg, et al.
Publicado: (2012)

HapX-Mediated Adaption to Iron Starvation Is Crucial for Virulence of Aspergillus fumigatus
por: Schrettl, Markus, et al.
Publicado: (2010)

The lineage-specific, intrinsically disordered N-terminal extension of monothiol glutaredoxin 1 from trypanosomes contains a regulatory region
por: Sturlese, Mattia, et al.
Publicado: (2018)

Altered intracellular calcium homeostasis and endoplasmic reticulum redox state in Saccharomyces cerevisiae cells lacking Grx6 glutaredoxin
por: Puigpinós, Judit, et al.
Publicado: (2015)

The Glutaredoxin Gene, grxB, Affects Acid Tolerance, Surface Hydrophobicity, Auto-Aggregation, and Biofilm Formation in Cronobacter sakazakii
por: Ling, Na, et al.
Publicado: (2018)

Characterization of the impact of glutaredoxin-2 (GRX2) deficiency on superoxide/hydrogen peroxide release from cardiac and liver mitochondria
por: Chalker, Julia, et al.
Publicado: (2017)

A Rice CPYC-Type Glutaredoxin OsGRX20 in Protection against Bacterial Blight, Methyl Viologen and Salt Stresses
por: Ning, Xi, et al.
Publicado: (2018)

Integrative analysis of the heat shock response in Aspergillus fumigatus
por: Albrecht, Daniela, et al.
Publicado: (2010)

Azole Resistance-Associated Regulatory Motifs within the Promoter of cyp51A in Aspergillus fumigatus
por: Kühbacher, Alexander, et al.
Publicado: (2022)

Monothiol and dithiol glutaredoxin-1 from Clostridium oremlandii: identification of domain-swapped structures by NMR, X-ray crystallography and HDX mass spectrometry
por: Lee, Kitaik, et al.
Publicado: (2020)

Overexpression of a CPYC-Type Glutaredoxin, OsGrxC2.2, Causes Abnormal Embryos and an Increased Grain Weight in Rice
por: Liu, Shengjie, et al.
Publicado: (2019)

The metalloreductase FreB is involved in adaptation of Aspergillus fumigatus to iron starvation
por: Blatzer, Michael, et al.
Publicado: (2011)

Interference of Aspergillus fumigatus with the immune response
por: Heinekamp, Thorsten, et al.
Publicado: (2014)

Iron-sensing is governed by mitochondrial, not by cytosolic iron–sulfur cluster biogenesis in Aspergillus fumigatus
por: Misslinger, Matthias, et al.
Publicado: (2018)

The leucine biosynthetic pathway is crucial for adaptation to iron starvation and virulence in Aspergillus fumigatus
por: Orasch, Thomas, et al.
Publicado: (2019)

The Siderophore Transporters Sit1 and Sit2 Are Essential for Utilization of Ferrichrome-, Ferrioxamine- and Coprogen-Type Siderophores in Aspergillus fumigatus
por: Aguiar, Mario, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_21di7m1c7c685p4b0q45c2kci0